Principal Scientist/Associate Director - RNA Therapy Biology / Program Management Job at Qilu Pharmaceutical, Boston, MA

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  • Qilu Pharmaceutical
  • Boston, MA

Job Description

About the Role

Qilu Pharmaceuticals, a leading pharmaceutical and biopharmaceutical company in China, with three innovation centers in the U.S., is expanding its RNA therapy team. We seek a highly motivated and experienced scientist to lead efforts in advancing RNA-based therapeutics. This role offers two potential directions based on expertise and career aspirations:

  1. RNA Therapy Biology: Focused on developing siRNA therapeutics targeting liver, extrahepatic, and neurological diseases.
  2. Program Management: Overseeing drug discovery programs, evaluating new therapeutic targets, and managing cross-functional collaborations.

Potential Directions

1. RNA Therapy Biology Focus

This track emphasizes leading scientific initiatives in RNA therapeutics, particularly siRNA drug discovery and development.

Primary Responsibilities:

  • Oversee multiple programs developing siRNA therapeutics, from target identification to candidate selection.
  • Stay updated on competitive landscapes in RNA-based modalities (siRNA, ASO, mRNA, etc.).
  • Design and execute preclinical proof-of-concept studies in relevant therapeutic areas (liver, extrahepatic, CNS).
  • Manage global CROs and external partnerships, ensuring quality and timely execution.
  • Train and mentor junior scientists, research associates, ensuring adherence to best practices and SOPs.
  • Present findings to project teams, governance bodies, and external scientific audiences.

Qualifications:

  • Ph.D. in Biology, Pharmacology, Molecular Biology, or a related discipline with 5+ years of industry experience.
  • Deep understanding of RNAi mechanisms, PK/PD relationships, and oligonucleotide drug discovery.
  • Strong expertise in preclinical model development for RNA therapeutics.
  • Experience managing external collaborations, including CRO partnerships.
  • Excellent communication skills in English (Chinese proficiency is a plus).
  • Strong leadership, organizational, and project management skills.

2. Program Management Focus

This track is ideal for individuals with experience in drug discovery program management, target evaluation, and cross-functional leadership.

Primary Responsibilities:

  • Identify and assess novel therapeutic targets, ensuring translational feasibility.
  • Coordinate cross-functional teams (biology, chemistry, bioinformatics) to drive projects forward.
  • Develop and implement assays for target engagement, potency, and mechanism-of-action studies.
  • Support drug discovery programs from early-stage research through critical development milestones.
  • Ensure project deliverables are met on time and within budget.
  • Present data and strategic insights to internal stakeholders and external partners.
  • Contribute to publications, patents, and regulatory documentation.

Qualifications:

  • Ph.D. in Molecular Biology, Biochemistry, Neuroscience, or a related field with 5+ years of industry experience.
  • Proven track record in program management within biotech/pharmaceutical R&D.
  • Strong background in oligonucleotide therapeutics (siRNA, ASO, mRNA) is preferred.
  • Experience in assay development for drug discovery applications is preferred.
  • Excellent leadership and cross-functional collaboration skills.
  • Ability to thrive in a fast-paced, dynamic research environment.

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